Dichloromethane → HCID 20499026、化合物

HRID 128335

反応式

HRID 128335 の反応式
Cl.[CH:2]1([CH2:8][NH:9][C:10]2[CH:20]=[CH:19][C:13]([CH2:14][CH2:15][C:16](Cl)=[O:17])=[CH:12][CH:11]=2)[CH2:7][CH2:6][CH:5]=[CH:4][CH2:3]1.C(Cl)Cl.[OH:24][CH:25]([CH2:30][CH3:31])[C:26]([O:28][CH3:29])=[O:27].C(N(CC)CC)C>CCOCC>[CH:2]1([CH2:8][NH:9][C:10]2[CH:20]=[CH:19][C:13]([CH2:14][CH2:15][C:16]([O:24][CH:25]([C:26]([O:28][CH3:29])=[O:27])[CH2:30][CH3:31])=[O:17])=[CH:12][CH:11]=2)[CH2:7][CH2:6][CH:5]=[CH:4][CH2:3]1

参加物

6

反応物 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 520445Methyl 2-hydroxybutanoateHCID 20498938HCID 20498938、化合物

生成物 1

HCID 20499026HCID 20499026、化合物

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To a solution of 10.0 g. 4-(cyclohex-3-enylmethylamino)hydrocinnamoyl chloride hydrochloride in 200 ml. methylene chloride is added dropwise a solution of 3 g. methyl 2-hydroxybutyrate and 5 g. triethylamine in 100 ml. ether. After 17 hours stirring at room temperature, the precipitate is collected and washed with several portions of ether. The ether solution is washed with water, dried and evaporated to yield 1-(methoxycarbonyl)propyl 4-(cyclohex-3-enylmethylamino)hydrocinnamate as a white solid.

後処理

  1. customthe precipitate is collected
  2. washwashed with several portions of ether
  3. washThe ether solution is washed with water
  4. customdried
  5. customevaporated

出典と根拠

ORDレコード
ord-ea03a9192e7447e3bb69d05468adc2b6
出典データセット
uspto-grants-1981_03
特許番号
US04259352

関連ノート

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