Thiomorpholine 1-oxide → HCID 54325127、化合物

HRID 1283451

反応式

HRID 1283451 の反応式
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[C:6]([NH2:11])[N:5]=[C:4]([S:12][CH3:13])[N:3]=1.[NH:14]1[CH2:19][CH2:18][S:17](=[O:20])[CH2:16][CH2:15]1>CC(C)=O>[NH2:11][C:6]1[N:5]=[C:4]([S:12][CH3:13])[N:3]=[C:2]([N:14]2[CH2:19][CH2:18][S:17](=[O:20])[CH2:16][CH2:15]2)[C:7]=1[N+:8]([O-:10])=[O:9]

参加物

4

反応物 2

HCID 12600299Thiomorpholine 1-oxideHCID 148930356-Chloro-2-(methylthio)-5-nitropyrimidin-4-amine

生成物 1

HCID 54325127HCID 54325127、化合物収率 78.2%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒2 回

実験手順

3.08 gm (0.014 mol) of 4-chloro-6-amino-2-methylthio-5-nitro-pyrimidine were dissolved in 50 ml of acetone, and a solution of 3.2 gm (0.027 mol) of thiomorpholine-1-oxide in 20 ml of acetone was added dropwise at room temperature, while stirring. After stirring the mixture for 1.5 hours more, ice was added to the reaction mixture, and the yellow precipitate formed thereby was suction-filtered off and recrystallized from ethanol. Yield: 78.2% of theory; m.p. 239°-242°C.

後処理

  1. stirringAfter stirring the mixture for 1.5 hours more
  2. additionice was added to the reaction mixture
  3. customthe yellow precipitate formed
  4. filtrationthereby was suction-filtered off
  5. customrecrystallized from ethanol

出典と根拠

ORDレコード
ord-f57267dff38147d3a0896ed41a317141
出典データセット
uspto-grants-1976_08
特許番号
US03975384

関連ノート

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