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Thiomorpholine 1-oxide → HCID 54325127、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thiomorpholine 1-oxide | HCID 12600299 | — |
| 反応物 | 6-Chloro-2-(methylthio)-5-nitropyrimidin-4-amine | HCID 14893035 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | HCID 54325127 | HCID 54325127 | 78.2% |
反応手順
3.08 gm (0.014 mol) of 4-chloro-6-amino-2-methylthio-5-nitro-pyrimidine were dissolved in 50 ml of acetone, and a solution of 3.2 gm (0.027 mol) of thiomorpholine-1-oxide in 20 ml of acetone was added dropwise at room temperature, while stirring. After stirring the mixture for 1.5 hours more, ice was added to the reaction mixture, and the yellow precipitate formed thereby was suction-filtered off and recrystallized from ethanol. Yield: 78.2% of theory; m.p. 239°-242°C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03975384 |
| 出典データセット | uspto-grants-1976_08 |
| ORD ID | ord-f57267dff38147d3a0896ed41a317141 |
| 出典メモ | uspto-grants-1976_08 |