Sodium Cyanide → 2-Amino-5-fluorobenzonitrile

HRID 1283710

反応式

HRID 1283710 の反応式
[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4](I)[CH:3]=1.[C-:10]#[N:11].[Na+]>N1C=CC=CC=1>[C:10]([C:4]1[CH:3]=[C:2]([F:1])[CH:8]=[CH:7][C:5]=1[NH2:6])#[N:11]

参加物

4

反応物 2

HCID 8929Sodium CyanideHCID 27782834-Fluoro-2-iodoaniline

生成物 1

HCID 27377042-Amino-5-fluorobenzonitrile

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

Fifteen grams of cuprous cyanide and 14 g. of dry pyridine are heated to a homogeneous melt. After adding 25.0 g. of 4-fluoro-2-iodoaniline, the mixture is heated at about 160°-170° C. for two hours. To the cooled mixture, concentrated sodium cyanide solution is added. The solid material is filtered off and extracted with benzene. The benzene extracts are concentrated and fractionally distilled to give 2-cyano-4-fluoroaniline.

後処理

  1. additionAfter adding 25.0 g
  2. filtrationThe solid material is filtered off
  3. extractionextracted with benzene
  4. concentrationThe benzene extracts are concentrated
  5. distillationfractionally distilled

出典と根拠

ORDレコード
ord-993385d6121a41b18f4d4c4b7409be99
出典データセット
uspto-grants-1976_08
特許番号
USRE028939

関連ノート

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