Triethylamine → (S)-Methyl 2-((methoxycarbonyl)amino)-3-phenylpropanoate
反応式
[CH3:1][O:2][C:3]([NH:5][C@H:6]([C:14]([OH:16])=[O:15])[CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:4].[CH2:17](N(CC)CC)C.COC(ON=C(C#N)C(OCC)=O)=O>C(Cl)(Cl)Cl>[CH3:17][O:15][C:14](=[O:16])[C@H:6]([CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[NH:5][C:3]([O:2][CH3:1])=[O:4]参加物
5
実験手順
To a suspension of N-methoxycarbonyl-L-phenylalanine (1.65 g) and triethylamine (2.8 ml) in dry chloroform (15 ml), ethyl 2-methoxycarbonyloxyimino-2-cyanoacetate (4.0 g) is added, and the resulting mixture is stirred at room temperature for 2 hours. The reaction mixture is treated as in Example B to give N-methoxycarbonyl-L-phenylalanine methyl ester (1.2 g) as an oil.
後処理
- additionis added
- additionThe reaction mixture is treated as in Example B
出典と根拠
- ORDレコード
- ord-eb4b89aa01e84856b720efd2f17fa960
- 出典データセット
- uspto-grants-1976_08
- 特許番号
- US03976635
反応ノート
読み込み中…