Hexylamine → HCID 21516712、化合物

HRID 1283841

反応式

HRID 1283841 の反応式
[N+](C1C=CC(O[C:11](=[O:27])[CH:12]2[CH2:16][CH2:15][CH2:14][N:13]2[C:17]([O:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[O:18])=CC=1)([O-])=O.[CH2:28]([NH2:34])[CH2:29][CH2:30][CH2:31][CH2:32][CH3:33]>O1CCCC1>[CH2:20]([O:19][C:17]([N:13]1[CH2:14][CH2:15][CH2:16][CH:12]1[C:11]([NH:34][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])=[O:27])=[O:18])[C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1

参加物

4

反応物 2

HCID 8102HexylamineHCID 1029701-Benzyl 2-(4-nitrophenyl) pyrrolidine-1,2-dicarboxylate

生成物 1

HCID 21516712HCID 21516712、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To a solution of 25.9 g. (0.07 mol.) of N-carbobenzoxy-DL-proline p-nitrophenyl ester in 250 ml. of dry tetrahydrofuran is added 14.1 g. (0.140 mol.) of n-hexylamine in 50 ml. of tetrahydrofuran, and the resulting solution is left overnight at room temperature. The solvent is removed in vacuo, the residue is diluted with ether, and this solution is then washed thoroughly with 1 N aqueous sodium hydroxide, water and then dilute hydrochloric acid. On drying the ether solution and concentrating in vacuo, a pale yellow oil comprising 1-[(benzyloxy)carbonyl]-2-[(hexylamino)carbonyl]pyrrolidine is obtained.

後処理

  1. customThe solvent is removed in vacuo
  2. additionthe residue is diluted with ether
  3. washthis solution is then washed thoroughly with 1 N aqueous sodium hydroxide, water
  4. dry with materialOn drying the ether solution
  5. concentrationconcentrating in vacuo

出典と根拠

ORDレコード
ord-568e739eac7d4250803e1e8c44164ee0
出典データセット
uspto-grants-1976_08
特許番号
US03976660

関連ノート

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