Hydrochloric Acid → Hydrochloric Acid
反応式
C[O:2][C:3]([C@@H:5]([NH2:12])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:4].[ClH:13]>>[CH:9]1[CH:8]=[CH:7][C:6]([C@H:5]([NH2:12])[C:3]([OH:4])=[O:2])=[CH:11][CH:10]=1.[ClH:13]参加物
4
実験手順
A solution of methyl L-phenylglycinate (-)-hemitartrate mono-ethanol solvate ([α]D + 62.4°, 36.888 g., 0.102 mole) in 6N-hydrochloric acid (68 ml., 0.408 mole, 4 equiv.) was refluxed for 1 hour 10 minutes and then distilled for 15 minutes. Water (68 ml.) was added and the pH of the warm solution adjusted to 7.0 with ammonium hydroxide solution (0.880, 35 ml.). The mixture was cooled in ice, filtered, and the solid was washed with water (2 × 25 ml.) and ethanol (25 ml.) and dried over phosphorus pentoxide to give L-phenylglycine as white plates (13.406 g., 87%), [α]D21 + 152.1° (c 1.007, 1N-HCl).
後処理
- distillationdistilled for 15 minutes
- additionWater (68 ml.) was added
- temperatureThe mixture was cooled in ice
- filtrationfiltered
- washthe solid was washed with water (2 × 25 ml.) and ethanol (25 ml.)
- dry with materialdried over phosphorus pentoxide
出典と根拠
- ORDレコード
- ord-a0bc9825e8164839830096a5db6176ac
- 出典データセット
- uspto-grants-1976_08
- 特許番号
- US03976680
反応ノート
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