DL-alanine → 2,3-Dicyano-5-(1-carboxyethyl)amino-6-phenylpyrazine

HRID 128397

反応式

HRID 128397 の反応式
[C:1]([C:3]1[C:8]([C:9]#[N:10])=[N:7][C:6](Cl)=[C:5]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:4]=1)#[N:2].[CH3:18][CH:19]([NH2:23])[C:20]([OH:22])=[O:21].[OH-].[Na+].O>CC(C)=O>[C:1]([C:3]1[C:8]([C:9]#[N:10])=[N:7][C:6]([NH:23][CH:19]([C:20]([OH:22])=[O:21])[CH3:18])=[C:5]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:4]=1)#[N:2]

参加物

6

反応物 4

HCID 602DL-alanineHCID 962WaterHCID 14798Sodium HydroxideHCID 129072055-Chloro-6-phenylpyrazine-2,3-dicarbonitrile

生成物 1

HCID 133369692,3-Dicyano-5-(1-carboxyethyl)amino-6-phenylpyrazine収率 42%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

2,3-Dicyano-5-chloro-6-phenylpyrazine (4.82 g; 0.02 mole) was dissolved in 50 ml of acetone. The solution was cooled to 0° to 5° C., and with stirring, a solution prepared from 1.78 g (0.02 mole) of DL-α-alanine, 1.64 g (0.02 mole) of sodium hydroxide and 40 ml of water was added dropwise over the period of 30 minutes. The mixture was worked up in the same way as in Example 23, and recrystallized from benzene to afford 2.46 g (yield 42%) of 2,3-dicyano-5-(1-caroxyethyl)amino-6-phenylpyrazine.

後処理

  1. temperatureThe solution was cooled to 0° to 5° C.
  2. additionwas added dropwise over the period of 30 minutes
  3. customrecrystallized from benzene

出典と根拠

ORDレコード
ord-a2f9eef30b7e412db563be5317c91516
出典データセット
uspto-grants-1981_03
特許番号
US04259489

関連ノート

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