Hydrazine hydrate (1:1) → 5-Hydrazino-1,3-dihydropyrrolo[4,3,2-de]isoquinoline

HRID 1284032ノート

反応式

HRID 1284032 の反応式
C(O[C:4]1[C:13]2[CH:12]=[CH:11][CH:10]=[C:9]3[NH:14][CH:15]=[C:7]([C:8]=23)[CH2:6][N:5]=1)C.O.[NH2:17][NH2:18]>CO>[NH:17]([C:4]1[C:13]2[CH:12]=[CH:11][CH:10]=[C:9]3[NH:14][CH:15]=[C:7]([C:8]=23)[CH2:6][N:5]=1)[NH2:18]

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 215155225-Ethoxy-1,3-dihydropyrrolo[4,3,2-de]isoquinoline

生成物 1

HCID 30410875-Hydrazino-1,3-dihydropyrrolo[4,3,2-de]isoquinoline

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

A solution of 5-ethoxy-1,3-dihydropyrrolo[4,3,2-de]isoquinoline (10.0 g), described in Example 5, in methanol (100 ml) is combined with a solution of hydrazine hydrate (3 g) in methanol (150 ml). After boiling overnight the mixture is concentrated to half of its original volume and diluted with ether. The resulting precipitate is collected to give the title compound, mp 188° - 189°C, νmaxnujol 3370, 3325, 3150, 1628, 1583, 1540 and 1510 cm-1.

後処理

  1. concentrationthe mixture is concentrated to half of its original volume
  2. additiondiluted with ether
  3. customThe resulting precipitate is collected

出典と根拠

ORDレコード
ord-b872ab6c2b594ecfb26287bca44f897b
出典データセット
uspto-grants-1976_08
特許番号
US03978066

反応ノート

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