Imidazole → HCID 20491388、化合物

HRID 1284074ノート

反応式

HRID 1284074 の反応式
[C:1]1([C:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)(Cl)[C:8]#[N:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH:17]1[CH:21]=[CH:20][N:19]=[CH:18]1.O>C(#N)C>[C:1]1([C:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)([C:18]2[NH:17][CH:21]=[CH:20][N:19]=2)[C:8]#[N:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

5

反応物 3

HCID 795ImidazoleHCID 962WaterHCID 11075152alpha-Chloro-alpha-phenylbenzeneacetonitrile

生成物 1

HCID 20491388HCID 20491388、化合物

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

5.9 g diphenyl-chloroacetonitrile (prepared from diphenyl-chloroacetamide, Ber. 41, 3593 by heating in phosphorus oxychloride; b.p. 130°C./0.4 mm Hg) are heated with 5 g imidazole in 50 ml acetonitrile at boiling temperature for 18 hours. After treating with 20 ml of water, the mixture is extracted with methylene chloride. The solvent is distilled off after drying in a vacuum. The solid residue is recrystallized from ethyl acetate/petroleum ether. Diphenyl-imidazolyl-acetonitrile i.e. diphenyl-imidazolyl-acetic acid nitrile of m.p. 98°C. is thus obtained.

後処理

  1. customfor 18 hours
  2. extractionthe mixture is extracted with methylene chloride
  3. distillationThe solvent is distilled off
  4. customafter drying in a vacuum
  5. customThe solid residue is recrystallized from ethyl acetate/petroleum ether

出典と根拠

ORDレコード
ord-631d2e2e78994bb2858a20e0cd87358b
出典データセット
uspto-grants-1976_08
特許番号
US03978069

反応ノート

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