Pyridine → HCID 21453097、化合物
反応式
N1C=CC=CC=1.[S:7]([NH:11][C:12]([NH2:14])=[O:13])([CH3:10])(=[O:9])=[O:8].[C:15](Cl)([Cl:17])=[O:16]>ClCCl>[S:7]([NH:11][C:12]([NH:14][C:15]([Cl:17])=[O:16])=[O:13])([CH3:10])(=[O:9])=[O:8]参加物
5
実験手順
6.1 parts by volume of pyridine were added dropwise, while cooling, to a mixture of 10.5 parts by weight of N-mesylurea, 60 parts by volume of dichloromethane and 15.0 parts by weight of phosgene, while cooling, and after some hours at 0°C the excess of the phosgene was removed, the precipitate present was filtered off and the filtrate was completely concentrated in vacuo. A viscous oil remained, which had an absorption at 1800 cm-1 in the carbonyl region of the IR-spectrum. The substance was used without further purification for the production of the penicillin.
後処理
- temperaturewhile cooling
- customafter some hours at 0°C the excess of the phosgene was removed
- filtrationthe precipitate present was filtered off
- concentrationthe filtrate was completely concentrated in vacuo
- customan absorption at 1800 cm-1 in the carbonyl region of the IR-spectrum
- customThe substance was used without further purification for the production of the penicillin
出典と根拠
- ORDレコード
- ord-f213e09676c84499906c41e8caee8009
- 出典データセット
- uspto-grants-1976_08
- 特許番号
- US03978056
反応ノート
読み込み中…