Ammonia → 5-(1-Methylethyl)-8-phenyl-1,3-dioxolo(4,5-g)quinazolin-6(5H)-one

HRID 1284158ノート

反応式

HRID 1284158 の反応式
FC(F)(F)[C:3]([N:5]([CH:23]([CH3:25])[CH3:24])[C:6]1[CH:19]=[C:18]2[O:20][CH2:21][O:22][C:17]2=[CH:16][C:7]=1[C:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=O)=[O:4].[NH3:28]>O1CCCC1>[CH:23]([N:5]1[C:6]2[C:7](=[CH:16][C:17]3[O:22][CH2:21][O:20][C:18]=3[CH:19]=2)[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[N:28][C:3]1=[O:4])([CH3:25])[CH3:24]

参加物

4

反応物 2

HCID 222AmmoniaHCID 215156622-(N-trifluoroacetylisopropylamino)-4,5-methylenedioxybenzophenone

生成物 1

HCID 363315-(1-Methylethyl)-8-phenyl-1,3-dioxolo(4,5-g)quinazolin-6(5H)-one

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of 1.0 g. of 2-(N-trifluoroacetylisopropylamino)-4,5-methylenedioxybenzophenone (prepared as in Example C) and 50 ml. of tetrahydrofuran saturated with anhydrous ammonia is stirred at room temperature for 48 hours. The solvent is removed in vacuo and the residue recrystallized from isopropanol to give 1-isopropyl-4-phenyl-6,7-methylenedioxy-2(1H)-quinazolinone, m.p. 189°-190°C.

後処理

  1. additionA mixture of 1.0 g
  2. customThe solvent is removed in vacuo
  3. customthe residue recrystallized from isopropanol

出典と根拠

ORDレコード
ord-7cb795cd1ff446ef8ade630ed8e14f83
出典データセット
uspto-grants-1976_08
特許番号
US03978086

反応ノート

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