Acetic Acid → 2-[1-(p-Chlorophenyl)-1H-1,2,4-triazol-5-yl]pyrazine

HRID 128453

反応式

HRID 128453 の反応式
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][NH2:10])=[CH:5][CH:4]=1.[OH-].[Na+].C(O)(=O)C.CN([CH:20]=[N:21][C:22]([C:24]1[CH:29]=[N:28][CH:27]=[CH:26][N:25]=1)=O)C>O1CCOCC1>[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:22]([C:24]3[CH:29]=[N:28][CH:27]=[CH:26][N:25]=3)=[N:21][CH:20]=[N:10]2)=[CH:5][CH:4]=1

参加物

6

反応物 4

HCID 176Acetic AcidHCID 14798Sodium HydroxideHCID 71600Hydrazine, (4-chlorophenyl)-, hydrochloride (1:1)HCID 16727655N-[(Dimethylamino)methylene]pyrazine-2-carboxamide

生成物 1

HCID 128502962-[1-(p-Chlorophenyl)-1H-1,2,4-triazol-5-yl]pyrazine

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

To a solution of 12.1 g. of 4-chlorophenylhydrazine hydrochloride in a mixture of 13.5 ml. of 5 N sodium hydroxide, 100 ml. of 30% aqueous acetic acid and 50 ml. of p-dioxane is added 10.0 g. of N-(dimethylaminomethylene)pyrazinecarboxamide. The procedure of Example 2 is then followed giving 3.8 g. of the desired product as tan crystals, mp. 129°-131° C.

後処理

  1. customThe procedure of Example 2 is then followed giving 3.8 g

出典と根拠

ORDレコード
ord-329fadb526ba4417a783d3ae4f2cc47c
出典データセット
uspto-grants-1981_03
特許番号
US04259504

関連ノート

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