Hydrazine hydrate (1:1) → 3-(4-Phenylpiperazin-1-yl)propan-1-amine

HRID 1284630

反応式

HRID 1284630 の反応式
[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][CH2:15][N:16]3C(=O)C4=CC=CC=C4C3=O)[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O.NN>C(O)C>[C:1]1([N:7]2[CH2:8][CH2:9][N:10]([CH2:13][CH2:14][CH2:15][NH2:16])[CH2:11][CH2:12]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 64248092-[3-(4-Phenyl-piperazin-1-yl)-propyl]-isoindole-1,3-dione

生成物 1

HCID 2612973-(4-Phenylpiperazin-1-yl)propan-1-amine収率 97.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of N-[3-(4-phenyl-1-piperazinyl)propyl]phthalimide (18.3 g) in ethanol (300 ml) was added 100% hydrazine hydrate (5.3 g). The resulting mixture was refluxed with stirring for 2 hours. The reaction mixture was evaporated under reduced pressure. After the addition of dil aqueous solution of sodium hydroxide to the residue, the mixture was extracted with chloroform. The extract was washed with water, dried over magnesium sulfate and then evaporated under reduced pressure to give 3-(4-phenyl-1-piperazinyl)propylamine (11.2 g).

後処理

  1. temperatureThe resulting mixture was refluxed
  2. customThe reaction mixture was evaporated under reduced pressure
  3. additionAfter the addition of dil aqueous solution of sodium hydroxide to the residue
  4. extractionthe mixture was extracted with chloroform
  5. washThe extract was washed with water
  6. dry with materialdried over magnesium sulfate
  7. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-ec7a3e0d59884719a71c632f804aaf86
出典データセット
uspto-grants-1986_01
特許番号
US04563524

関連ノート

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