反応式
[C:1]([O:11]CC(N)CC)(=[O:10])[C@@H:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[OH:3]>O>[C:1]([OH:11])(=[O:10])[C@@H:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[OH:3]参加物
3
実験手順
A portion of the (-)-2-amino-1-butanol D-(-)-mandelate wet cake 155 grams "as is"--90.3% pure; 0.58 mole) from resolution A is dissolved in the mother liquor plus water washes from (D) at 50°-55° C. and the solution is distilled under vacuum to remove 41 mls of methanol and water. The concentrated solution is then treated with 37% hydrochloric acid (60 mls) and processed as described in (D) to obtain 77 grams of D-(-)-mandelic acid (87.4% of theoretical; m.p. 130°-132° C.; [α]D25° =-152.9° (C=2, H2O)).
後処理
- distillationthe solution is distilled under vacuum
- customto remove 41 mls of methanol and water
- additionThe concentrated solution is then treated with 37% hydrochloric acid (60 mls)
出典と根拠
- ORDレコード
- ord-654ea6ac1d2a42b2bccff9c70292501b
- 出典データセット
- uspto-grants-1981_03
- 特許番号
- US04259521
関連ノート
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