Monobenzone → 4-[4-(Trifluoromethoxy)-2-nitrophenoxy]-phenyl benzyl ether

HRID 128494

反応式

HRID 128494 の反応式
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C[O-].[K+].[F:19][C:20]([F:33])([F:32])[O:21][C:22]1[CH:27]=[CH:26][C:25](Cl)=[C:24]([N+:29]([O-:31])=[O:30])[CH:23]=1>CN(C=O)C>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([O:15][C:25]2[CH:26]=[CH:27][C:22]([O:21][C:20]([F:33])([F:19])[F:32])=[CH:23][C:24]=2[N+:29]([O-:31])=[O:30])=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 7638MonobenzoneHCID 232972111-Chloro-2-nitro-4-(trifluoromethoxy)benzeneHCID 23664618Potassium methoxide

生成物 1

HCID 234698274-[4-(Trifluoromethoxy)-2-nitrophenoxy]-phenyl benzyl ether

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a mixture of 10.01 g. of 4-(benzyloxy)phenol and 3.51 g. (0.05 mole) of potassium methoxide in 75 ml. of DMF is added 12.08 g. (0.05 mole) of 4-(trifluoromethoxy)-2-nitro-1-chlorobenzene. The mixture is heated to complete the reaction. Most of the solvent is removed at reduced pressure and the residue treated with methylene chloride and water. The methylene chloride solution is washed with saturated brine, dried, and the solvent removed, leaving 4-[4-(trifluoromethoxy)-2-nitrophenoxy]-phenyl benzyl ether.

後処理

  1. additionTo a mixture of 10.01 g
  2. temperatureThe mixture is heated
  3. customthe reaction
  4. customMost of the solvent is removed at reduced pressure
  5. additionthe residue treated with methylene chloride and water
  6. washThe methylene chloride solution is washed with saturated brine
  7. customdried
  8. customthe solvent removed

出典と根拠

ORDレコード
ord-1391ff6e4cd44424a79ed88c9d8f6738
出典データセット
uspto-grants-1981_03
特許番号
US04259532

関連ノート

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