Thionyl Chloride → 2-[[4-[4-(Trifluoromethoxy)phenoxy]phenoxy]]propanoyl chloride

HRID 128495ノート

反応式

HRID 128495 の反応式
[F:1][C:2]([F:24])([F:23])[O:3][C:4]1[CH:22]=[CH:21][C:7]([O:8][C:9]2[CH:20]=[CH:19][C:12]([O:13][CH:14]([CH3:18])[C:15](O)=[O:16])=[CH:11][CH:10]=2)=[CH:6][CH:5]=1.S(Cl)([Cl:27])=O>CN(C=O)C>[F:1][C:2]([F:24])([F:23])[O:3][C:4]1[CH:22]=[CH:21][C:7]([O:8][C:9]2[CH:20]=[CH:19][C:12]([O:13][CH:14]([CH3:18])[C:15]([Cl:27])=[O:16])=[CH:11][CH:10]=2)=[CH:6][CH:5]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 234698242-[[4-[4-(Trifluoromethoxy)phenoxy]phenoxy]]propanoic acid

生成物 1

HCID 234698232-[[4-[4-(Trifluoromethoxy)phenoxy]phenoxy]]propanoyl chloride

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To 17.11 g. (0.05 mole) of 2-[[4-[4-(trifluoromethoxy)phenoxy]phenoxy]]propanoic acid is added 1 ml. of DMF, followed by 50 ml. of thionyl chloride. After evolution of HCl ceases, the thionyl chloride excess is removed in vacuum. The residue is extracted with methylene chloride and the methylene chloride solution washed with ice water, dried, and the solvent removed, leaving 2-[[4-[4-(trifluoromethoxy)phenoxy]-phenoxy]]propanoyl chloride.

後処理

  1. customAfter evolution of HCl ceases, the thionyl chloride excess is removed in vacuum
  2. extractionThe residue is extracted with methylene chloride
  3. washthe methylene chloride solution washed with ice water
  4. customdried
  5. customthe solvent removed

出典と根拠

ORDレコード
ord-f45e87b23fb34b9daf983d84e798b337
出典データセット
uspto-grants-1981_03
特許番号
US04259532

反応ノート

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