Methylamine → 2-[[4-[4-(trifluoromethoxy)phenoxy]phenoxy]]propanoic acid, N-methyl amide

HRID 128496ノート

反応式

HRID 128496 の反応式
[F:1][C:2]([F:24])([F:23])[O:3][C:4]1[CH:22]=[CH:21][C:7]([O:8][C:9]2[CH:20]=[CH:19][C:12]([O:13][CH:14]([CH3:18])[C:15](Cl)=[O:16])=[CH:11][CH:10]=2)=[CH:6][CH:5]=1.[CH3:25][NH2:26]>O1CCCC1>[CH3:25][NH:26][C:15](=[O:16])[CH:14]([O:13][C:12]1[CH:19]=[CH:20][C:9]([O:8][C:7]2[CH:21]=[CH:22][C:4]([O:3][C:2]([F:24])([F:23])[F:1])=[CH:5][CH:6]=2)=[CH:10][CH:11]=1)[CH3:18]

参加物

4

反応物 2

HCID 6329MethylamineHCID 234698232-[[4-[4-(Trifluoromethoxy)phenoxy]phenoxy]]propanoyl chloride

生成物 1

HCID 867368562-[[4-[4-(trifluoromethoxy)phenoxy]phenoxy]]propanoic acid, N-methyl amide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Into a solution of 3.61 g. (0.01 mole) of 2-[[4-[4-(trifluoromethoxy)phenoxy]phenoxy]]propanoyl chloride in 20 ml. of tetrahydrofuran (THF) is passed a stream of gaseous methylamine. When the reaction is over, the solvent is removed and the residue treated with methylene chloride. The methylene chloride solution is washed with water, dried, and the solvent removed, providing a residue of 2-[[4-[4-(trifluoromethoxy)phenoxy]phenoxy]]propanoic acid, N-methyl amide.

後処理

  1. customis removed
  2. additionthe residue treated with methylene chloride
  3. washThe methylene chloride solution is washed with water
  4. customdried
  5. customthe solvent removed

出典と根拠

ORDレコード
ord-182e19ef3f4b4ee09dc841751b2838ae
出典データセット
uspto-grants-1981_03
特許番号
US04259532

反応ノート

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