Glycine, N,N-diethyl-, ethyl ester → 7-[(5-Diethylaminomethyl-1,2,4-oxadiazol-3-yl)-methyl]-theophylline

HRID 1285165

反応式

HRID 1285165 の反応式
[N:1]1([C:12](=[O:13])[C:11]2[N:10]([CH2:14][C:15](=[N:17][OH:18])[NH2:16])[CH:9]=[N:8][C:7]=2[N:5]([CH3:6])[C:3]1=[O:4])[CH3:2].C[O-].[Na+].C(O[C:25](=O)[CH2:26][N:27]([CH2:30][CH3:31])[CH2:28][CH3:29])C>CO>[CH2:26]([N:27]([CH2:30][C:31]1[O:18][N:17]=[C:15]([CH2:14][N:10]2[C:11]3[C:12](=[O:13])[N:1]([CH3:2])[C:3](=[O:4])[N:5]([CH3:6])[C:7]=3[N:8]=[CH:9]2)[N:16]=1)[CH2:28][CH3:29])[CH3:25]

参加物

5

反応物 3

HCID 75843Glycine, N,N-diethyl-, ethyl esterHCID 30574902-(Theophyllin-7-yl)-acetamidoximeHCID 10942334Sodium Methoxide

生成物 1

HCID 202499057-[(5-Diethylaminomethyl-1,2,4-oxadiazol-3-yl)-methyl]-theophylline収率 80%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

5.04 g. of 2-(theophyllin-7-yl)-acetamidoxime, 2.16 g. of sodium methylate, 6.37 g. of diethylamino acetic acid ethylester and 80 cm3 methanol are stirred for 10 hours at 100° C. in a closed system under pressure. 5.2 g. (80% yield) of 7-[(5-diethylaminomethyl-1,2,4-oxadiazol-3-yl)-methyl]-theophylline are obtained. m.p.: 69°-70° C. (cyclohexane).

出典と根拠

ORDレコード
ord-7ba5ad3d9278458889cbef3ce6d90db8
出典データセット
uspto-grants-1986_01
特許番号
US04565817

関連ノート

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