化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Iodide → 7H-Purine-7-butanenitrile, 1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Iodide | HCID 5238 | — |
| 反応物 | Sodium Cyanide | HCID 8929 | — |
| 反応物 | 7-(3-Chloropropyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione | HCID 76011 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 7H-Purine-7-butanenitrile, 1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo- | HCID 610234 | 88% |
反応手順
57.9 g. of 7-(3-chloro-propan-1-yl)-theophylline, 12.29 g. of sodium cyanide, 2.0 g. of sodium iodide and 400 cm3 of dimethylformamide are stirred at 90° C. for 3 hours. 49.1 g. (88% yield) of γ-(theophylline-7-yl)-butyronitrile are obtained. M.p.: 146°-150° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04565817 |
| 出典データセット | uspto-grants-1986_01 |
| ORD ID | ord-5775af0a11f74eaeac2e66a0d237763a |
| 出典メモ | uspto-grants-1986_01 |