huagongshe.com
HRID1285175

反应详情

EQUATION

反应方程式

HRID 1285175 的结构方程式

REACTANTS

反应物

3
结构：[I-].[Na+]
HCID5238

Sodium Iodide

INa

结构：[C-]#N.[Na+]
HCID8929

Sodium cyanide (Na(CN))

CNNa

结构：Cn1c(=O)c2c(ncn2CCCCl)n(C)c1=O
HCID76011

7-(3-Chloropropyl)theophylline

C10H13ClN4O2

PRODUCTS

生成物

1
结构：Cn1c(=O)c2c(ncn2CCCC#N)n(C)c1=O
HCID610234

7H-Purine-7-butanenitrile, 1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo-

C11H13N5O2

收率 88%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

57.9 g. of 7-(3-chloro-propan-1-yl)-theophylline, 12.29 g. of sodium cyanide, 2.0 g. of sodium iodide and 400 cm3 of dimethylformamide are stirred at 90° C. for 3 hours. 49.1 g. (88% yield) of γ-(theophylline-7-yl)-butyronitrile are obtained. M.p.: 146°-150° C.