Hydrochloric Acid → 4-Methyl-1H-imidazole-5-carboxylic acid
反応式
[OH-].[Na+].[CH3:3][C:4]1[NH:8][CH:7]=[N:6][C:5]=1[C:9]([O:11]CC)=[O:10].Cl>O>[CH3:3][C:4]1[NH:8][CH:7]=[N:6][C:5]=1[C:9]([OH:11])=[O:10]参加物
5
実験手順
Sodium hydroxide (70.0 g, 1.75 moles), followed by ethyl 5-methyl-1H-imidazole-4-carboxylate (34.0 g, 0.22 mole), were added to 500 ml of water. The reaction mixture was stirred and heated at reflux for one hour, cooled in an ice bath, and neutralized with 150 ml of concentrated hydrochloric acid. The precipitated solid was collected and dried to give 5-methyl-1H-imidazole-4-carboxylic acid.
後処理
- temperatureheated
- temperatureat reflux for one hour
- temperaturecooled in an ice bath
- customThe precipitated solid was collected
- customdried
出典と根拠
- ORDレコード
- ord-bf81dec674f3433a8f965bf21cfc7740
- 出典データセット
- uspto-grants-1986_01
- 特許番号
- US04565875
反応ノート
読み込み中…