Sodium Carbonate → HCID 20565165、化合物

HRID 1285270ノート

反応式

HRID 1285270 の反応式
[C:1]([NH:4][C:5]1[CH:18]=[CH:17][C:8]([NH:9][CH2:10][CH2:11][NH:12][S:13]([CH3:16])(=[O:15])=[O:14])=[CH:7][CH:6]=1)(=[O:3])[CH3:2].C(=O)([O-])[O-].[Na+].[Na+].[CH2:25]([OH:28])[CH2:26]Br>O>[C:1]([NH:4][C:5]1[CH:18]=[CH:17][C:8]([N:9]([CH2:26][CH2:25][OH:28])[CH2:10][CH2:11][NH:12][S:13]([CH3:16])(=[O:15])=[O:14])=[CH:7][CH:6]=1)(=[O:3])[CH3:2]

参加物

5

反応物 3

HCID 10340Sodium CarbonateHCID 108982-BromoethanolHCID 20248673HCID 20248673、化合物

生成物 1

HCID 20565165HCID 20565165、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

0.037 mol (10 g) of 4-acetylamino-N-(β-mesylaminoethyl)-aniline is dissolved in 31 ml of boiling water. 7.4 g of sodium carbonate and 0.148 mol (18.5 g) of glycol bromohydrin are added, whilst stirring. After stirring for 4 hours in a boiling water bath, the reaction medium is filtered and the filtrate is then left to stand for 48 hours at 0° C. The 4-acetylamino-N-(β-hydroxyethyl)-N-mesylaminoethylaniline which has precipitated in crystalline form is filtered off. After recrystallisation from boiling water and drying in vacuo, the product melts at 118° C.

後処理

  1. stirringAfter stirring for 4 hours in a boiling water bath
  2. filtrationthe reaction medium is filtered
  3. waitthe filtrate is then left
  4. customThe 4-acetylamino-N-(β-hydroxyethyl)-N-mesylaminoethylaniline which has precipitated in crystalline form
  5. filtrationis filtered off
  6. customAfter recrystallisation
  7. customdrying in vacuo

出典と根拠

ORDレコード
ord-85945c479141423e9410b3a46bfd0287
出典データセット
uspto-grants-1986_01
特許番号
US04566875

反応ノート

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