Formaldehyde → 4-(2-Chlorophenyl)-1-(hydroxymethyl)-1H-pyrrole-3-carbonitrile

HRID 1285298ノート

反応式

HRID 1285298 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:12]([C:13]#[N:14])=[CH:11][NH:10][CH:9]=1.[CH2:15]=[O:16]>C(N(CC)CC)C>[OH:16][CH2:15][N:10]1[CH:11]=[C:12]([C:13]#[N:14])[C:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[Cl:1])=[CH:9]1

参加物

4

反応物 2

HCID 712FormaldehydeHCID 128035354-(2-Chlorophenyl)-1H-pyrrole-3-carbonitrile

生成物 1

HCID 202487964-(2-Chlorophenyl)-1-(hydroxymethyl)-1H-pyrrole-3-carbonitrile

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

反応条件

温度
90 °C

実験手順

60.8 g of 3-(2-chlorophenyl)-4-cyanopyrrole, 9.9 g of paraformaldehyde and 0.8 g of triethylamine are thoroughly mixed and and the mixture is then heated, with stirring, at a bath temperature of 90° C. The resultant melt is cooled to room temperature after 11/4 hours, when it congeals to a glass-like solid. Recrystallisation from toluene yields the title compound in the form of brownish crystals of m.p. 94°-97° C.

後処理

  1. temperaturethe mixture is then heated
  2. temperatureThe resultant melt is cooled to room temperature after 11/4 hours, when it
  3. customRecrystallisation from toluene

出典と根拠

ORDレコード
ord-21a6f0eb51ee4d82affee7fc86034e8c
出典データセット
uspto-grants-1986_01
特許番号
US04567052

反応ノート

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