Ethanol → 4,6-Dibromo-3-fluoro-2-methylbenzoic acid

HRID 1286ノート

反応式

HRID 1286 の反応式
[CH3:1][C:2]1[C:11]([F:12])=[C:10]([Br:13])[CH:9]=[C:8]([Br:14])[C:3]=1[C:4]([O:6]C)=[O:5].C(O)C.[OH-].[Na+]>O>[CH3:1][C:2]1[C:11]([F:12])=[C:10]([Br:13])[CH:9]=[C:8]([Br:14])[C:3]=1[C:4]([OH:6])=[O:5]

参加物

5

反応物 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 189744684,6-Dibromo-3-fluoro-2-methyl-benzoic acid methylester

生成物 1

HCID 146512824,6-Dibromo-3-fluoro-2-methylbenzoic acid収率 84.4%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To methyl 2-methyl-3-fluoro-4,6-dibromobenzoate (75.5 g) are added ethanol (460 ml) and 10% aqueous solution of sodium hydroxide (460 ml) and the mixture is refluxed for 2 hours. After cooling, the reaction mixture is diluted with water and extracted with diethyl ether. The aqueous layer is made acidic with conc. hydrochloric acid and extracted with diethyl ether. The solvent is concentrated to give 2-methyl-3-fluoro-4,6-dibromobenzoic acid (61 g), m.p. 144°-146° C.

後処理

  1. temperaturethe mixture is refluxed for 2 hours
  2. temperatureAfter cooling
  3. extractionextracted with diethyl ether
  4. extractionextracted with diethyl ether
  5. concentrationThe solvent is concentrated

出典と根拠

ORDレコード
ord-1b1dfc28218048f1b96339ca5954f763
出典データセット
uspto-grants-1998_03
特許番号
US05723648

反応ノート

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