Hydrochloric Acid → 4-(2-(Diethylamino)ethoxy)aniline

HRID 128620

反応式

HRID 128620 の反応式
[CH2:1]([N:3]([CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][CH:10]=1)[CH2:4][CH3:5])[CH3:2].Cl.[OH-].[Na+]>O>[CH2:1]([N:3]([CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][CH:10]=1)[CH2:4][CH3:5])[CH3:2]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 88294Diethyl[2-(4-nitrophenoxy)ethyl]amine

生成物 1

HCID 4189324-(2-(Diethylamino)ethoxy)aniline

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

N,N-Diethyl-2-(4-nitrophenoxy)ethylamine (4.0 g) (prepared by the method described in Helv. Chim. Acta. 1960, 43, 1971) was dissolved in IMS (70 ml), water (10 ml) and concentrated hydrochloric acid (2 ml). The mixture was boiled under reflux and then reduced iron powder (4.6 g) was carefully added in portions. The mixture was boiled under reflux for 7 hours then hot filtered. The filtrate was basified with 5M sodium hydroxide solution and then evaporated under reduced pressure. The residue was partitioned between water and ether. The organic layer was separated, dried and evaporated to give 4-[2-(N,N-diethylamino)ethoxy]aniline as an oil.

後処理

  1. temperatureunder reflux
  2. temperatureunder reflux for 7 hours
  3. customevaporated under reduced pressure
  4. customThe residue was partitioned between water and ether
  5. customThe organic layer was separated
  6. customdried
  7. customevaporated

出典と根拠

ORDレコード
ord-093748d8a4c444aba0ba587ee5938d8f
出典データセット
uspto-grants-1995_11
特許番号
US05464781

関連ノート

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