4-Hydroxy-3,5-bis(isopropyl)benzaldehyde → 5-[[4-Hydroxy-3,5-bis(1-methylethyl)phenyl]methylene]-2-thioxo-4-imidazolidinone

HRID 128733

反応式

HRID 128733 の反応式
[OH:1][C:2]1[C:9]([CH:10]([CH3:12])[CH3:11])=[CH:8][C:5]([CH:6]=O)=[CH:4][C:3]=1[CH:13]([CH3:15])[CH3:14].[NH:16]1[CH2:22][C:20](=[O:21])[NH:19][C:17]1=[S:18].C([O-])(=O)C.[Na+]>C(O)(=O)C>[OH:1][C:2]1[C:9]([CH:10]([CH3:12])[CH3:11])=[CH:8][C:5]([CH:6]=[C:22]2[NH:16][C:17](=[S:18])[NH:19][C:20]2=[O:21])=[CH:4][C:3]=1[CH:13]([CH3:15])[CH3:14]

参加物

5

反応物 3

HCID 827124-Hydroxy-3,5-bis(isopropyl)benzaldehydeHCID 517045Sodium AcetateHCID 12740302-Thiohydantoin

生成物 1

HCID 539462155-[[4-Hydroxy-3,5-bis(1-methylethyl)phenyl]methylene]-2-thioxo-4-imidazolidinone収率 32.9%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

Prepared according to the procedure described in Example 1 using 4-hydroxy-3,5-bis(1-methylethyl)benzaldehyde (3.0 g, 15 mmoles), 2-thiohydantoin (1.6 g, 14 mmoles), sodium acetate (4.2 g, 51 mmoles), and acetic acid (35 ml), filtered off, dried, and recrystallized from acetonitrile to afford the pure product (1.4 g), mp 225°-230° C.

後処理

  1. customPrepared
  2. filtrationfiltered off
  3. customdried
  4. customrecrystallized from acetonitrile

出典と根拠

ORDレコード
ord-94182eba54ee4fcc8316740632dfd6a6
出典データセット
uspto-grants-1995_11
特許番号
US05464856

関連ノート

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