Acetone → HCID 178444022、化合物

HRID 1287409ノート

反応式

HRID 1287409 の反応式
[Na].CC(C)=O.Cl.[C:7]([NH2:15])(=[NH:14])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13].[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][C:18]=1[N:27]=[C:28]=[S:29]>C1C=CC=CC=1.CCCCCC>[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][C:18]=1[NH:27][C:28]([NH:14][C:7](=[NH:15])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])=[S:29]

参加物

6

反応物 4

HCID 180Acetone2 回HCID 1410052-Chloro-5-trifluoromethylphenyl isothiocyanateHCID 5360545SodiumHCID 14144282Heptanimidamide hydrochloride

生成物 1

HCID 178444022HCID 178444022、化合物

試薬・触媒・溶媒 1

HCID 110624Benzene hexane溶媒

実験手順

Following a procedure similar to that described in Example 42 but using 1.86 g. sodium in 250 ml. dry acetone, 13.4 g. heptanamidine hydrochloride, and 19.2 g. 2-chloro-5-(trifluoromethyl)phenyl isothiocyanate [prepared from 2-chloro-5-(trifluoromethyl)aniline] in 70 ml. acetone there was obtained 1-[2-chloro-5-(trifluoromethyl)phenyl]-3-(heptanimidoyl)-2-thiourea, m.p. 88°-90°C. (from benzene-n-hexane); hydrochloride (10.3 g.), m.p. 160°-161°C. (from acetonitrile).

出典と根拠

ORDレコード
ord-5ff1e34663a94de3b26991ae5a7821f4
出典データセット
uspto-grants-1976_10
特許番号
US03984467

反応ノート

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