Ethyl benzoylacetate → HCID 178434713、化合物
反応式
C(O[C:4](=[O:14])[CH2:5][C:6](=O)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)C.[NH2:15][C:16]1[O:20][N:19]=[C:18]([CH3:21])[CH:17]=1>O>[CH3:21][C:18]1[C:17]2[C:4]([OH:14])=[CH:5][C:6]([C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=3)=[N:15][C:16]=2[O:20][N:19]=1参加物
4
実験手順
19.2 g. of benzoylacetic acid ethyl ester (0.1 mol.) are added dropwise to a stirred mixture of 9.8 g. of 5-amino-3-methylisoxazole (0.1 mol.) and 50 g. of polyphosphorous acid heated to 120°-125°. After the reaction has occurred, which can be recognized by changing of the color to brown, the reaction mixture is heated for an additional half hour at 125°. After the mixture has cooled to room temperature, 250 ml. of water are added in portions and stirring is continued until the compound becomes crystalline. The collected 3-methyl-6-phenylisoxazolo[5,4-b]pyridin-4-ol is washed with water, dried and recrystallized from ethanol yielding 19.9 g. (88%), m.p. 281°-282°.