Diethylamine → Trans-N,N,N',N'-tetraethyl-1,2-dimethylcyclohex-1-ene-4,5-dicarboxamide

HRID 128772ノート

反応式

HRID 128772 の反応式
[CH3:1][C:2]1[CH2:7][C@@H:6]([C:8]([OH:10])=O)[C@H:5]([C:11]([OH:13])=O)[CH2:4][C:3]=1[CH3:14].S(Cl)(Cl)=O.[CH2:19]([NH:21][CH2:22][CH3:23])[CH3:20]>C(OCC)C>[CH2:19]([N:21]([CH2:22][CH3:23])[C:8]([C@H:6]1[C@H:5]([C:11]([N:21]([CH2:22][CH3:23])[CH2:19][CH3:20])=[O:13])[CH2:4][C:3]([CH3:14])=[C:2]([CH3:1])[CH2:7]1)=[O:10])[CH3:20]

参加物

5

反応物 3

HCID 8021DiethylamineHCID 24386Thionyl ChlorideHCID 738867trans-1,2-Dimethylcyclohexene-4,5-dicarboxylic acid

生成物 1

HCID 67746645Trans-N,N,N',N'-tetraethyl-1,2-dimethylcyclohex-1-ene-4,5-dicarboxamide

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To trans-1,2-dimethylcyclohexene-4,5-dicarboxylic acid (1.98 g 0.01 mol) heated to 80° C., was added thionyl chloride (2.38 g, 0.02 mol) over 1 hr. The mixture was kept at this temperature for a further two hours, then cooled and added dropwise to a diethyl ether solution (45 ml) of excess diethylamine (14.6 g, 0.2 mol) cooled to ice bath temperature. The solvent was removed to give the crude product as an oil which was not purified for use in the next stage.

後処理

  1. temperaturecooled
  2. temperaturecooled to ice bath temperature
  3. customThe solvent was removed

出典と根拠

ORDレコード
ord-8bddd387f21d4a6a8aebe4fbe66f786c
出典データセット
uspto-grants-1995_11
特許番号
US05464873

反応ノート

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