O-Toluidine → 1-Methyl-N-(2-methylphenyl)cyclohexane-1-carboxamide

HRID 1288042

反応式

HRID 1288042 の反応式
[CH3:1][C:2]1([C:8](Cl)=[O:9])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.C(=O)([O-])[O-].[K+].[K+].[NH2:17][C:18]1[C:19]([CH3:24])=[CH:20][CH:21]=[CH:22][CH:23]=1>C1(C)C=CC=CC=1>[CH3:1][C:2]1([C:8]([NH:17][C:18]2[C:19]([CH3:24])=[CH:20][CH:21]=[CH:22][CH:23]=2)=[O:9])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1

参加物

5

反応物 3

HCID 7242O-ToluidineHCID 11430Potassium CarbonateHCID 41892451-Methylcyclohexanecarbonyl chloride

生成物 1

HCID 127516481-Methyl-N-(2-methylphenyl)cyclohexane-1-carboxamide

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A mixture of 32.7 grams (0.203 moles) of 1-methyl-1-cyclohexanecarboxylic acid chloride, 15.2 grams (0.11 mole) of anhydrous potassium carbonate and 21.8 grams (0.203 mole) of o-toluidine in 260 ml. of dry toluene is stirred and refluxed for 2.5 hours. The inorganic salts are removed by filtration and the filtrate is concentrated in vacuuo. The residue yields from diethyl ether-pentane 40.5 grams (87%) of N-(1-methylcyclohexyl carbonyl)-o-toluidine; m.p. 138° C.

後処理

  1. temperaturerefluxed for 2.5 hours
  2. customThe inorganic salts are removed by filtration
  3. concentrationthe filtrate is concentrated in vacuuo

出典と根拠

ORDレコード
ord-e549e00b74e4479fa38b5559650dafbe
出典データセット
uspto-grants-1976_10
特許番号
US03987059

関連ノート

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