Water → 2-Phenoxy-1-propanamine

HRID 1288230

反応式

HRID 1288230 の反応式
[O:1]([CH:8]([CH3:11])[C:9]#[N:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].O.[OH-].[Na+]>CCOCC>[O:1]([CH:8]([CH3:11])[CH2:9][NH2:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

6

反応物 4

HCID 962Water2 回HCID 14798Sodium HydroxideHCID 190944362-PhenoxypropanenitrileHCID 21226445Aluminium lithium hydride

生成物 1

HCID 37183552-Phenoxy-1-propanamine

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

A solution of 2-phenoxypropionitrile (11.0 s.) in dry ether (50 ml.) was added dropwise to a stirred suspension of lithium aluminium hydride (3.8 g.) in dry ether (50 ml.). The mixture was then heated to reflux for 3 hours, cooled and treated cautiously (vigorous stirring) with water (3.8 ml.) then with 15% aqueous sodium hydroxide (3.8 ml.) and finally with water (11.4 ml.). The mixture was stirred for 20 minutes and filtered. The filtrate was dried over anhydrous potassium carbonate and evaporated. The residue was distilled under water-pump vacuum to give pure 2-phenoxypropylamine, b.p. 115°-116°/15 mm.

後処理

  1. temperatureThe mixture was then heated
  2. temperatureto reflux for 3 hours
  3. temperaturecooled
  4. additiontreated cautiously
  5. filtrationfiltered
  6. dry with materialThe filtrate was dried over anhydrous potassium carbonate
  7. customevaporated
  8. distillationThe residue was distilled under water-pump vacuum

出典と根拠

ORDレコード
ord-6a922e13d3f2425987de5b5a5296ee3b
出典データセット
uspto-grants-1976_10
特許番号
US03987158

関連ノート

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