Water → 2-Propanamine, 1-(3-methylphenoxy)-

HRID 1288233ノート

反応式

HRID 1288233 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([CH:11]=[CH:12][CH:13]=1)[O:5][CH2:6][C:7](=[N:9]O)[CH3:8].[H-].[Al+3].[Li+].[H-].[H-].[H-].O.[OH-].[Na+]>CCOCC>[CH3:1][C:2]1[CH:3]=[C:4]([CH:11]=[CH:12][CH:13]=1)[O:5][CH2:6][CH:7]([NH2:9])[CH3:8]

参加物

6

反応物 4

HCID 962Water2 回HCID 14798Sodium HydroxideHCID 21226445Aluminium lithium hydrideHCID 85437759HCID 85437759、化合物

生成物 1

HCID 122988962-Propanamine, 1-(3-methylphenoxy)-

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

A solution of 1-(3-methylphenoxy)propan-2-one oxime (13.7 g.) in dry ether (100 ml.) was added dropwise, over 45 minutes, to a stirred, refluxing mixture of lithium aluminium hydride (5.85 g.) in dry ether (200 ml.). Stirring and heating were continued for 4 hours and the mixture was cooled and treated cautiously with water (5.8 ml.) followed by 15% aqueous sodium hydroxide (5.8 ml.), and finally, water (17.5 ml.). The mixture was stirred for 30 minutes and then filtered. The filtrate was dried over anhydrous potassium carbonate and evaporated. The residue was distilled to give 1-(3-methylphenoxy)prop-2-ylamine, b.p. 124°-128°/13 mm.

後処理

  1. temperaturerefluxing
  2. temperatureheating
  3. temperaturethe mixture was cooled
  4. stirringThe mixture was stirred for 30 minutes
  5. filtrationfiltered
  6. dry with materialThe filtrate was dried over anhydrous potassium carbonate
  7. customevaporated
  8. distillationThe residue was distilled

出典と根拠

ORDレコード
ord-ab449766ab784b499fd2ecb646f60432
出典データセット
uspto-grants-1976_10
特許番号
US03987158

反応ノート

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