Hydrogen Bromide → HCID 21482727、化合物
反応式
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:4]=[C:5]([S:10]([NH2:13])(=[O:12])=[O:11])[CH:6]=[CH:7][C:8]=1[NH2:9].[BrH:16].BrBr>O>[NH2:9][C:8]1[C:3]([C:2]([F:1])([F:14])[F:15])=[CH:4][C:5]([S:10]([NH2:13])(=[O:12])=[O:11])=[CH:6][C:7]=1[Br:16]参加物
5
実験手順
A suspension of 0.69 g. (0.029 moles) of 3-trifluoromethyl-4-aminobenzenesulfonamide in 7 ml. of water and 7 ml. of 48% hydrobromic acid is treated dropwise with 0.16 ml. of liquid bromine and stirred for 3 hours at room temperature. The reaction mixture is filtered, the solid material washed with 10% aqueous sodium bicarbonate, water and dried. The dried solid is recrystallized from toluene affording 0.76 g. of 4-amino-3-bromo-5-trifluoromethylbenzenesulfonamide, m.p. 248°-252° C.
後処理
- additionA suspension of 0.69 g
- filtrationThe reaction mixture is filtered
- washthe solid material washed with 10% aqueous sodium bicarbonate, water
- customdried
- customThe dried solid is recrystallized from toluene affording 0.76 g
出典と根拠
- ORDレコード
- ord-9c6e6cea41d44a87821ff7d163708aec
- 出典データセット
- uspto-grants-1976_10
- 特許番号
- US03987199
反応ノート
読み込み中…