2-methyl-N-[2-nitro-4-(trifluoromethyl)phenyl]propanamide → N-[2-Amino-4-(trifluoromethyl)phenyl]-2-methylpropanamide
反応式
[N+:1]([C:4]1[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[CH:12][C:5]=1[NH:6][C:7](=[O:11])[CH:8]([CH3:10])[CH3:9])([O-])=O.[H][H]>C(O)C.[Pd]>[NH2:1][C:4]1[CH:15]=[C:14]([C:16]([F:17])([F:18])[F:19])[CH:13]=[CH:12][C:5]=1[NH:6][C:7](=[O:11])[CH:8]([CH3:10])[CH3:9]参加物
5
実験手順
Shake 85 g. of 2'-nitro-4'-trifluoromethylisobutyranilide in 1.0 liter of ethanol containing 3.0 g. of 5% palladium on charcoal in a parr shaker under approximately 50 lbs. per square inch hydrogen pressure for twenty-four hours. Filter, remove the ethanol and recrystallize from a dichloromethane-chloroform-hexane mixture, obtaining the product of this step.
後処理
- filtrationFilter
- customremove the ethanol
- customrecrystallize from a dichloromethane-chloroform-hexane mixture
- customobtaining the product of this step
出典と根拠
- ORDレコード
- ord-0f249124da3a4f41b82e5e36446a9729
- 出典データセット
- uspto-grants-1976_10
- 特許番号
- US03987182
反応ノート
読み込み中…