Hydrochloric Acid → 9-Methyltetrazolo[1,5-a]quinoxaline

HRID 1288325ノート

反応式

HRID 1288325 の反応式
Cl[C:2]1[CH:3]=[N:4][C:5]2[C:10]([N:11]=1)=[C:9]([CH3:12])[CH:8]=[CH:7][CH:6]=2.[N-:13]=[N+:14]=[N-:15].[Na+].Cl>C(O)C>[CH3:12][C:9]1[CH:8]=[CH:7][CH:6]=[C:5]2[C:10]=1[N:11]1[N:13]=[N:14][N:15]=[C:2]1[CH:3]=[N:4]2

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 33557Sodium AzideHCID 215049212-Chloro-8-methylquinoxaline

生成物 1

HCID 215048979-Methyltetrazolo[1,5-a]quinoxaline

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

The crude 3-chloro-5-methylquinoxaline obtained in the step above was stirred for 3 hours at reflux temperature in 75 ml. of ethanol containing 1.8 g. of sodium azide and 20 ml. of 1N HCl. When the reaction mixture was cooled, the product precipitated as needles. Recrystallization of the product from ethanol produced highly purified 9-methyltetrazolo[1,5-a]quinoxaline, m.p. 166°-68° C. The product was identified by NMR analysis and by elemental microanalysis.______________________________________ Theoretical FoundC 58.37% 58.11%H 3.81 3.98N 37.82 37.60______________________________________

後処理

  1. temperatureat reflux temperature in 75 ml
  2. temperatureWhen the reaction mixture was cooled
  3. customthe product precipitated as needles
  4. customRecrystallization of the product from ethanol

出典と根拠

ORDレコード
ord-a6bd63ae652744e8b570c1052848e750
出典データセット
uspto-grants-1976_10
特許番号
US03987196

反応ノート

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