Dimethyl Sulfoxide → 7,8-Dichloro-1-methylisoquinoline

HRID 1288477ノート

反応式

HRID 1288477 の反応式
[Cl:1][C:2]1[C:11]([Cl:12])=[C:10]2[C:5]([CH:6]=[CH:7][N:8]=[CH:9]2)=[CH:4][CH:3]=1.[CH3:13]S(C)=O.[H-].[Na+]>O>[Cl:1][C:2]1[C:11]([Cl:12])=[C:10]2[C:5]([CH:6]=[CH:7][N:8]=[C:9]2[CH3:13])=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 679Dimethyl Sulfoxide2 回HCID 24758Sodium hydrideHCID 125950627,8-Dichloroisoquinoline

生成物 1

HCID 213938347,8-Dichloro-1-methylisoquinoline

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

反応条件

温度
70 °C

実験手順

7,8-Dichloroisoquinoline (0.019 mole) in 100 ml. of dimethylsulfoxide is added to a solution of sodium hydride (0.11 mole) in 100 ml. of dimethylsulfoxide at 70° C. The reaction mixture is stirred at 70° C. for 4 hours under a nitrogen atmosphere. The reaction mixture is cooled, 100 ml. of water is added, and the mixture is poured into 1500 ml. of water. The aqueous mixture is extracted with benzene. The extract is washed, dried over sodium sulfate and evaporated to give 7,8-dichloro-1-methylisoquinoline.

後処理

  1. customat 70° C
  2. temperatureThe reaction mixture is cooled
  3. additionthe mixture is poured into 1500 ml
  4. extractionThe aqueous mixture is extracted with benzene
  5. washThe extract is washed
  6. dry with materialdried over sodium sulfate
  7. customevaporated

出典と根拠

ORDレコード
ord-dd3e80d8e2844313aabb83c81a95059d
出典データセット
uspto-grants-1976_10
特許番号
US03988339

反応ノート

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