Sodium Carbonate → 1-[(6-Methylnaphthalen-2-yl)methyl]-4-(pyridin-2-yl)piperazine

HRID 1288570ノート

反応式

HRID 1288570 の反応式
Cl[CH2:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH3:13])[CH:9]=2)[CH:4]=1.C(=O)([O-])[O-].[Na+].[Na+].[N:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1>CN(C)C=O>[CH3:13][C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[CH:4]=[C:3]([CH2:2][N:29]1[CH2:30][CH2:31][N:26]([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][N:20]=3)[CH2:27][CH2:28]1)[CH:12]=[CH:11]2

参加物

5

反応物 3

HCID 10340Sodium CarbonateHCID 944591-(2-Pyridyl)piperazineHCID 133015572-(Chloromethyl)-6-methylnaphthalene

生成物 1

HCID 215029051-[(6-Methylnaphthalen-2-yl)methyl]-4-(pyridin-2-yl)piperazine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 11.0 g. of 2-chloromethyl-6-methylnaphthalene, 7.0 g. of sodium carbonate and 10.0 g. of 2-pyridylpiperazine in 75 ml. of dimethylformamide is stirred for six hours. The reaction mixture is cooled, filtered and the filtrate is concentrated. The precipitate is then washed with water and crystallized from ethanol to yield 1-(6-methyl-β-naphthylmethyl)-4-(2-pyridyl)piperazine.

後処理

  1. additionA mixture of 11.0 g
  2. temperatureThe reaction mixture is cooled
  3. filtrationfiltered
  4. concentrationthe filtrate is concentrated
  5. washThe precipitate is then washed with water
  6. customcrystallized from ethanol

出典と根拠

ORDレコード
ord-f2b254025cd644c7b169da9058ff52bd
出典データセット
uspto-grants-1976_10
特許番号
US03988457

反応ノート

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