Glycidol → 3-(Octadecylamino)propane-1,2-diol

HRID 128894

反応式

HRID 128894 の反応式
[CH2:1]([NH2:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].[CH2:20]1[O:22][CH:21]1[CH2:23][OH:24]>CO>[CH2:1]([NH:19][CH2:20][CH:21]([OH:22])[CH2:23][OH:24])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]

参加物

4

反応物 2

HCID 11164GlycidolHCID 15793Octadecylamine

生成物 1

HCID 1200883-(Octadecylamino)propane-1,2-diol収率 95.9%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
60 °C

実験手順

Octadecylamine (18 g) was dissolved in 200 ml methanol and heated to 60° C. Glycidol (4.95 g) was added dropwise under constant stirring over one and half hours. The reaction mixture was kept under reflux for one additional hour, and then cooled to room temperature, and evaporated to dryness, resulting in 22 g white solid material. This was then recrystallized from hexane, to yield ODP, mp 81°-83° C.

後処理

  1. temperatureunder reflux for one additional hour
  2. temperaturecooled to room temperature
  3. customevaporated to dryness

出典と根拠

ORDレコード
ord-f27d6f854cac411c9ea3585343c87e9f
出典データセット
uspto-grants-1995_11
特許番号
US05466438

関連ノート

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