Methyl iodide → 2-Methoxy-4-phenoxybromobenzene

HRID 1289181ノート

反応式

HRID 1289181 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:4][C:3]=1[OH:15].[C:16]([O-])([O-])=O.[K+].[K+].IC>CC(C)=O>[CH3:16][O:15][C:3]1[CH:4]=[C:5]([O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:6]=[CH:7][C:2]=1[Br:1]

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 189257712-Bromo-5-phenoxyphenol

生成物 1

HCID 189257722-Methoxy-4-phenoxybromobenzene収率 92.1%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a solution of 2-bromo-5-phenoxyphenol (0.38 g, 1.4 mmol) in 6 ml acetone was added K2CO3 (0.58 g, 4.2 mmol) and iodomethane (0.26 ml, 4.2 mmol). The-reaction mixture was heated to reflux for 8 h, cooled to ambient temperature and filtered. The solvent was removed under reduced pressure and the residue was taken up in EtOAc. The organic phase was washed with 1N NaOH, water and brine. Drying over Na2SO4 afforded 0.36 g (92%) of 2-methoxy-4-phenoxybromobenzene.

後処理

  1. customThe-reaction mixture
  2. temperaturewas heated
  3. temperatureto reflux for 8 h
  4. filtrationfiltered
  5. customThe solvent was removed under reduced pressure
  6. washThe organic phase was washed with 1N NaOH, water and brine
  7. dry with materialDrying over Na2SO4

出典と根拠

ORDレコード
ord-5df851b9137742cdb02a7035877fd118
出典データセット
uspto-grants-1998_05
特許番号
US05747540

反応ノート

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