HCID 178451026、化合物 → HCID 178451021、化合物

HRID 1289256ノート

反応式

HRID 1289256 の反応式
C(OC([NH:11][C@@H:12]([C:22]1[NH:26][N:25]=[N:24][N:23]=1)[CH2:13][CH2:14][C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])=O)C1C=CC=CC=1>C(O)C.[Pd]>[NH2:11][C@@H:12]([C:22]1[NH:26][N:25]=[N:24][N:23]=1)[CH2:13][CH2:14][C:15]([O:17][C:18]([CH3:19])([CH3:20])[CH3:21])=[O:16]

参加物

4

反応物 1

HCID 178451026HCID 178451026、化合物

生成物 1

HCID 178451021HCID 178451021、化合物収率 91.1%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A solution of tert-butyl (4R)-4-(benzyloxycarbonylamino)-4-(tetrazol-5-yl)-butyrate (1.2 g, 3.32 mmol) in ethanol (77 ml) was stirred with 10% Pd-C (0.166 g) under a hydrogen atmosphere at ambient temperature for 16 hours. The catalyst was removed by filtration and the filtrate evaporated. Dichloromethane was added to the residue and evaporated and the resulting solid was triturated with hexane and dried to give tert-butyl (4R)-4-amino-4-(tetrazol-5-yl)butyrate (0.687 g, 91%), m.p. 175° C. (decomp.).

後処理

  1. customThe catalyst was removed by filtration
  2. customthe filtrate evaporated
  3. additionDichloromethane was added to the residue
  4. customevaporated
  5. customthe resulting solid was triturated with hexane
  6. customdried

出典と根拠

ORDレコード
ord-c51508cb4cc34c8a94fe0a217ee58be6
出典データセット
uspto-grants-1998_05
特許番号
US05747499

反応ノート

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