Carbon Dioxide → 4-(Decyloxy)-3-fluorobenzoic acid

HRID 1289339ノート

反応式

HRID 1289339 の反応式
C([Li])CCC.Br[C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])=[C:9]([F:24])[CH:8]=1.[C:25](=[O:27])=[O:26].Cl>C1COCC1.CCOCC>[CH2:14]([O:13][C:10]1[CH:11]=[CH:12][C:7]([C:25]([OH:27])=[O:26])=[CH:8][C:9]=1[F:24])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23]

参加物

7

反応物 4

HCID 280Carbon DioxideHCID 313Hydrochloric AcidHCID 146925094-Decyloxy-3-fluorophenyl bromideHCID 178418339Butyllithium

生成物 1

HCID 6399744-(Decyloxy)-3-fluorobenzoic acid

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of n-butyllithium was added dropwise to a stirred, cooled (-78° C.) solution of compound of step 2.1 in dry THF. The mixture was maintained under these conditions for 40 mins and then poured into a slurry of dry ether and cardice. The solution was acidified with 36% HCl, washed with water and dried (magnesium sulphate). The solvent was removed to yield a white solid.

後処理

  1. temperatureThe mixture was maintained under these conditions for 40 mins
  2. washwashed with water
  3. dry with materialdried (magnesium sulphate)
  4. customThe solvent was removed
  5. customto yield a white solid

出典と根拠

ORDレコード
ord-1090e088da22497eb8bcb2419e46c059
出典データセット
uspto-grants-1998_05
特許番号
US05750050

反応ノート

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