Trimethylsilyl iodide → 4-(Bromomethyl)cyclohexan-1-ol

HRID 1289349ノート

反応式

HRID 1289349 の反応式
C[O:2][CH:3]1[CH2:8][CH2:7][CH:6]([CH2:9][Br:10])[CH2:5][CH2:4]1.C[Si](I)(C)C>C(Cl)(Cl)Cl>[Br:10][CH2:9][CH:6]1[CH2:7][CH2:8][CH:3]([OH:2])[CH2:4][CH2:5]1

参加物

4

反応物 2

HCID 85247Trimethylsilyl iodideHCID 217065291-(Bromomethyl)-4-methoxycyclohexane

生成物 1

HCID 218327074-(Bromomethyl)cyclohexan-1-ol

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

The 4-methoxycyclohexylbromomethane compound (C-4) (2.6 g) in chloroform (7.8 g) was cooled with ice. Then trimethylsilyliodide (2.2 ml) was transferred to the C-4 solution. It was stirred at ambient temperature for 8 h, and then quenched with methanol. Then, volatiles were removed to obtain the desired alcohol in almost quantitative yield.

後処理

  1. customquenched with methanol
  2. customThen, volatiles were removed

出典と根拠

ORDレコード
ord-7df562be99754e0aaf4e0a7c5c27f733
出典データセット
uspto-grants-1998_05
特許番号
US05750300

反応ノート

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