Pyridine → HCID 18921566、化合物
反応式
[F:1][C:2]([F:14])([F:13])[C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][CH:7]=[CH:6]2.[Br:15]Br.N1C=CC=CC=1>ClC(Cl)(Cl)Cl>[Br:15][C:7]1[CH:8]=[N:9][C:10]2[C:5]([CH:6]=1)=[CH:4][C:3]([C:2]([F:1])([F:13])[F:14])=[CH:12][CH:11]=2参加物
5
実験手順
19.7 g of 6-trifluoromethyl-quinoline is introduced into 200 ml of tetrachloromethane. 5.2 ml of bromine is instilled and the solution is refluxed for one hour. Within twenty minutes, 7.9 g of pyridine in 8 ml of tetrachloromethane is instilled in the boiling solution. After one hour, it is allowed to cool, decanted from the precipitated salt and the solution is concentrated by evaporation. After column chromatography, 14.6 g of 3-bromo-6-trifluoromethyl-quinoline of melting point 79° C. is obtained.
後処理
- temperaturethe solution is refluxed for one hour
- waitWithin twenty minutes
- temperatureto cool
- customdecanted from the precipitated salt
- concentrationthe solution is concentrated by evaporation
出典と根拠
- ORDレコード
- ord-5dcd0cc6b6b646d4b45637753ec9eb4b
- 出典データセット
- uspto-grants-1998_05
- 特許番号
- US05750526
反応ノート
読み込み中…