2-Hydroxy-1,2,3-propanetricarboxylic acid hydrate (1:1) → HCID 178485755、化合物

HRID 1290076ノート

反応式

HRID 1290076 の反応式
[CH:1]1([CH2:7][C@H:8]([NH:19][C:20](=[O:49])[C@H:21]([CH2:43][C:44]2[N:48]=[CH:47][NH:46][CH:45]=2)[N:22]([CH3:42])[C:23](=[O:41])[C@H:24]([CH2:34][C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[NH:25][C:26]([N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[O:27])[C@@H:9]([OH:18])[CH2:10][C@H:11]2[C:15]([CH3:17])([CH3:16])[O:14][CH2:13][O:12]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.O.[C:51]([OH:63])(=[O:62])[CH2:52][C:53]([CH2:58][C:59]([OH:61])=[O:60])([C:55]([OH:57])=[O:56])[OH:54]>C(OCC)(=O)C>[C:51]([OH:63])(=[O:62])[CH2:52][C:53]([CH2:58][C:59]([OH:61])=[O:60])([C:55]([OH:57])=[O:56])[OH:54].[CH:1]1([CH2:7][C@H:8]([NH:19][C:20](=[O:49])[C@H:21]([CH2:43][C:44]2[N:48]=[CH:47][NH:46][CH:45]=2)[N:22]([CH3:42])[C:23](=[O:41])[C@H:24]([CH2:34][C:35]2[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=2)[NH:25][C:26]([N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[O:27])[C@@H:9]([OH:18])[CH2:10][C@H:11]2[C:15]([CH3:17])([CH3:16])[O:14][CH2:13][O:12]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 222302-Hydroxy-1,2,3-propanetricarboxylic acid hydrate (1:1)HCID 178485751HCID 178485751、化合物

生成物 1

HCID 178485755HCID 178485755、化合物収率 66.8%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒2 回

実験手順

The compound (300 mg) obtained in Example 1 was dissolved in ethyl acetate (3 ml) and a solution of citric acid monohydrate (92.7 mg) in ethyl acetate (5 ml) was dropwise added. After stirring at room temperature for 15 minutes, crystals were collected by filtration and dried under reduced pressure to give 257 mg of the title compound as white crystals (see Table 16).

後処理

  1. filtrationcrystals were collected by filtration
  2. customdried under reduced pressure

出典と根拠

ORDレコード
ord-ac2956440f2c436b8061b3693b6a8fb3
出典データセット
uspto-grants-1998_05
特許番号
US05750696

反応ノート

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