L-Tartaric acid → HCID 178485756、化合物

HRID 1290077ノート

反応式

HRID 1290077 の反応式
[CH:1]1([CH2:7][C@H:8]([NH:19][C:20](=[O:49])[C@H:21]([CH2:43][C:44]2[N:48]=[CH:47][NH:46][CH:45]=2)[N:22]([CH3:42])[C:23](=[O:41])[C@H:24]([CH2:34][C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[NH:25][C:26]([N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[O:27])[C@@H:9]([OH:18])[CH2:10][C@H:11]2[C:15]([CH3:17])([CH3:16])[O:14][CH2:13][O:12]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:50]([OH:59])(=[O:58])[C@@H:51]([C@H:53]([C:55]([OH:57])=[O:56])[OH:54])[OH:52]>C(OCC)(=O)C.C(O)C>[C:55]([C@@H:53]([C@H:51]([C:50]([OH:59])=[O:58])[OH:52])[OH:54])([OH:57])=[O:56].[CH:1]1([CH2:7][C@H:8]([NH:19][C:20](=[O:49])[C@H:21]([CH2:43][C:44]2[N:48]=[CH:47][NH:46][CH:45]=2)[N:22]([CH3:42])[C:23](=[O:41])[C@H:24]([CH2:34][C:35]2[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=2)[NH:25][C:26]([N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[O:27])[C@@H:9]([OH:18])[CH2:10][C@H:11]2[C:15]([CH3:17])([CH3:16])[O:14][CH2:13][O:12]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

5

反応物 2

HCID 444305L-Tartaric acidHCID 178485751HCID 178485751、化合物

生成物 1

HCID 178485756HCID 178485756、化合物収率 68.7%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 8857Ethyl Acetate溶媒2 回

実験手順

The compound (300 mg) obtained in Example 1 was dissolved in ethyl acetate (4.5 ml) and a solution of L-tartaric acid (66 mg) in ethyl acetate (5 ml) and ethanol (0.5 ml) was dropwise added. After stirring overnight at room temperature, crystals were collected by filtration and dried under reduced pressure to give 251 mg of the title compound as white crystals (see Table 16).

後処理

  1. filtrationcrystals were collected by filtration
  2. customdried under reduced pressure

出典と根拠

ORDレコード
ord-e6223c0ac8df4c57b301df180c926246
出典データセット
uspto-grants-1998_05
特許番号
US05750696

反応ノート

読み込み中…