4-Fluorophenol → Ethanethioic acid trans-(+/-)-S-[5-[(4-fluorophenoxy)methyl]tetrahydro-3-furanyl]ester

HRID 1290361ノート

反応式

HRID 1290361 の反応式
FC(F)(F)S([O:6][CH2:7][C@@H:8]1[O:12][CH2:11][C@@H:10]([S:13][C:14](=[O:16])[CH3:15])[CH2:9]1)(=O)=O.[F:19][C:20]1[CH:25]=[CH:24][C:23](O)=[CH:22][CH:21]=1.CCN(C(C)C)C(C)C>C(Cl)Cl>[F:19][C:20]1[CH:25]=[CH:24][C:23]([O:6][CH2:7][C@@H:8]2[O:12][CH2:11][C@@H:10]([S:13][C:14](=[O:16])[CH3:15])[CH2:9]2)=[CH:22][CH:21]=1

参加物

5

反応物 3

HCID 97324-FluorophenolHCID 81531DiisopropylethylamineHCID 86750748Ethanethioic acid trans(+/-)-S-[tetrahydro-5-[[[(trifluoromethyl)sulfonyl]oxy]methyl]-3-furanyl]ester

生成物 1

HCID 86750320Ethanethioic acid trans-(+/-)-S-[5-[(4-fluorophenoxy)methyl]tetrahydro-3-furanyl]ester収率 73.7%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

The title compound is prepared by the procedure of Example 23 using 1.49 g of product from Example 22 in 1 ml of methylene chloride, 0.542 g of 4-fluorophenol, 2.5 ml of Hunig's base and 3 ml of methylene chloride to give 0.963 g of the desired compound.

出典と根拠

ORDレコード
ord-cb52d3dd982d4485a34e8cc928132ceb
出典データセット
uspto-grants-1998_05
特許番号
US05750735

反応ノート

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