Potassium Hydroxide → 4-Methoxy-3-nitrobenzoic acid

HRID 1290696

反応式

HRID 1290696 の反応式
[N+:1]([C:4]1[C:5](C)=[C:6]([CH:10]=[CH:11][C:12]=1[O:13][CH3:14])[C:7]([O-:9])=[O:8])([O-:3])=[O:2].[OH-].[K+]>O1CCCC1>[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][C:12]=1[O:13][CH3:14])[C:7]([OH:9])=[O:8])([O-:3])=[O:2]

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 189170523-Nitro-4-methoxy-methylbenzoate

生成物 1

HCID 666404-Methoxy-3-nitrobenzoic acid収率 76.6%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a 500 ml erlenmeyer flask with magnetic stirrer was charged 10.3 g of 3-nitro4-methoxy-methylbenzoate, 400 ml tetrahydrofuran, and 3.2 g of 86% potassium hydroxide. The reaction was stirred for 12 hours at ambient temperature, after which the resulting solid was collected by vacuum filtration and washed with 2×100 ml of ethyl ether. The solid was dissolved in 200 ml of water and acidified to pH 4 with 6N hydrochloric acid. The resulting precipitate was collected by vacuum filtration, washed with 200 ml water, and dried overnight in vacuo at 30° C. Isolated 7.4 g of product as a white solid.

後処理

  1. filtrationafter which the resulting solid was collected by vacuum filtration
  2. washwashed with 2×100 ml of ethyl ether
  3. dissolutionThe solid was dissolved in 200 ml of water
  4. filtrationThe resulting precipitate was collected by vacuum filtration
  5. washwashed with 200 ml water
  6. customdried overnight in vacuo at 30° C

出典と根拠

ORDレコード
ord-fd4eff7937b14029a33cc68d8338781d
出典データセット
uspto-grants-1998_05
特許番号
US05753642

関連ノート

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