Cysteamine → HCID 22592849、化合物

HRID 1290697ノート

反応式

HRID 1290697 の反応式
Br[CH:2]([CH2:10]Br)[C:3]([O:5][C:6]([CH3:9])([CH3:8])[CH3:7])=[O:4].[SH:12][CH2:13][CH2:14][NH2:15].C(N(CC)CC)C.C(Cl)(Cl)Cl>C1C=CC=CC=1>[S:12]1[CH2:13][CH2:14][NH:15][CH:2]([C:3]([O:5][C:6]([CH3:9])([CH3:8])[CH3:7])=[O:4])[CH2:10]1

参加物

6

反応物 4

HCID 6058CysteamineHCID 6212ChloroformHCID 8471TriethylamineHCID 545325tert-Butyl 2,3-dibromopropanoate

生成物 1

HCID 22592849HCID 22592849、化合物

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

Preferably, t-butyl 2,3-dibromopropionate prepared according to J. Perkin Trans I, p. 1321 (1973) is treated with 2-mercaptoethylamine and triethylamine in a suitable solvent, such as a mixture of chloroform and benzene, to provide t-butyl tetrahydro-2H-1,4-thiazine-3-carboxylate, which upon reaction with a compound of the formula V under suitable conditions, such as in the presence of triethylamine in dichloromethane solution at 25° C., provides compounds of the formula II-c. Oxidation of this material with a suitable oxidizer, such as sodium perborate or m-chloroperbenzoic acid, provides the corresponding sulfoxide, preferably as a single diastereomer.

出典と根拠

ORDレコード
ord-5f3e20ce42644712b981f5ff5c7e84b2
出典データセット
uspto-grants-1998_05
特許番号
US05753653

反応ノート

読み込み中…