Benzoyl Peroxide → 7-(1-Bromoethyl)-1,2,4-triazolo[1,5-a]pyrimidine

HRID 1290802ノート

反応式

HRID 1290802 の反応式
[CH2:1]([C:3]1[N:8]2[N:9]=[CH:10][N:11]=[C:7]2[N:6]=[CH:5][CH:4]=1)[CH3:2].[Br:12]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>ClC(Cl)(Cl)Cl>[Br:12][CH:1]([C:3]1[N:8]2[N:9]=[CH:10][N:11]=[C:7]2[N:6]=[CH:5][CH:4]=1)[CH3:2]

参加物

5

反応物 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 189193537-Ethyl-1,2,4-triazolo[1,5-a]pyrimidine

生成物 1

HCID 189193517-(1-Bromoethyl)-1,2,4-triazolo[1,5-a]pyrimidine

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

A mixture of 7-ethyl-1,2,4-triazolo[1,5-a]pyrimidine (10.5 g), N-bromosuccinimide (12.63 g), dibenzoylperoxide (0.3 g) and tetrachloromethane (270 ml) was heated under reflux for 5 hours with stirring. The mixture was filtered and a crude product was obtained by evaporation of the solvent from the filtrate. This was purified by recrystallisation from tetrachloromethane to give 7-(1-bromoethyl)-1,2,4-triazolo[1,5-a]pyrimidine. Yield 10.8 g.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 5 hours
  3. filtrationThe mixture was filtered
  4. customa crude product was obtained by evaporation of the solvent from the filtrate
  5. customThis was purified by recrystallisation from tetrachloromethane

出典と根拠

ORDレコード
ord-500a3da8126445c6a19de442eeceb3b4
出典データセット
uspto-grants-1998_05
特許番号
US05753665

反応ノート

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